Definition of Peptic Ulcer
A state in which there is an incomplete coverage of that thick gastric-lining called as mucosa which protect sensitive tissues of gastric-system form dangerous affects of acid release in stomach which released in order to serve as an aid for digestion process.
Acid Re-flux is usually termed as GARD, definition exclude carcinoma and lymphoma (which are genre of hazardous cancers), viral infections, as the conclusion this acid-reflux also serve as a main cause of developing peptic-ulcer
Definition of Dyspepsia
Dyspepsia is characterized as persistent regular pain or discomfort centered in the upper abdomen,
Root-Causes of developing Dyspepsia
Peptic-ulcer is considered as a main culprit here!
Steps involved in development of Peptic-ulcer
two types of peptic-ulcer are of main consideration
one that is prevalent due to the micro-organism H.pylori, and the other type is due to excessive use of use of NSAIDs and less-commonly zollinger-ellison syndrome (in which elevation in acid-secretion is observed) is also a reason behind formation of peptic-ulcer.
Helicobacter pylori is a Gram Negative micro-organism found abundantly in the lower part of human stomach, 95% or more cases of anus-cancer and around 82-85% of stomach ulcer is associated with this virulent micro-organism H pylori, it basically produce cytotoxin associated genes known as Cag.A proteins which activate the domain hormone called “Gastrin” of host involved in triggering gastric-acid excretion,so that hyper-acidity results and body-homeostasis will suffer.
Nonsteroidal anti-inflammatory drug (NSAIDs)
more than 3 types of stomach-linning damage are caused by these drugs, which cause mild damage on stomach linning ultimately play a role in formation of of silent ulcer, weak-acids such as Aspirin are gathered with the acidic stomach-secretions into muscle cells and produce reversible short-term mild-damage by inhibiting an enzyme COX and by starting the sticking phenomenon of leukocytes to Red-Blood_cells a.k.a RBCs, the disgusting systemic effect of NSAIDs is that it involves into the reduction of stomach-linning prostaglandin-production, patients who are on chronic use of NSAIDs have a four-fold elevated risk of other complications compared with non-users.